Wiesje van der Flier, PhD, VU University Medical Center, Amsterdam, The Netherlands, discusses how advances in biomarker research are leading to improvements in the diagnosis of Alzheimer’s disease. Prof. van der Flier explains how past breakthroughs in biomarker research, such as discovering the presence of amyloid and tau in the cerebrospinal fluid (CSF), led to improvements in diagnostics and discusses how current research into blood-based biomarkers could lead to further progress. This interview took place during the European Academy of Neurology 2021 congress.