Thomas Meinel, MD, Bern University Hospital, and University of Bern, Bern, Switzerland, shares findings from a cohort study evaluating chronic covert brain infarction (CBI) phenotypes in first-ever ischemic stroke patients. This was a prospective, single-center study that included first-ever ischemic stroke patients with MRI on admission. Previous studies were limited by the use of CT imaging, which is not as sensitive or specific as MRI. It was found that the most frequent phenotype was lacunes, followed by combined grey and white matter lesions, isolated grey matter, and large subcortical non-cavitatory. Additionally, more than 1 in 3 patients had additional chronic lesions. This interview took place during the European Academy of Neurology 2021 congress.