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AAN 2022 | Neuronal complexity is reduced in chronic migraine and restored by HDAC6 inhibition

Amynah Pradhan, PhD, University of Illinois at Chicago, Chicago, IL, discusses a project evaluating the effects of HDAC6 inhibition in migraine chronicity and its potential as a migraine therapy. Two different preclinical mouse models of chronic migraine were used to determine whether there were changes in the neuronal complexity associated with chronic migraine. It was found that there was a significant decrease in neuronal complexity in pain and migraine precessing regions. Additionally, HDAC6 inhibition improved neuronal complexity and decreased cortical spreading depression, a physiological correlate of migraine aura. Notably, a calcitonin gene-related peptide (CGRP) receptor antagonist was also tested and restored neuronal complexity. This study directly shows that manipulation of cytoskeletal dynamics can restore neuronal complexity, and effective migraine therapies might include agents that restore microtubule/neuronal plasticity. This interview took place at the American Academy of Neurology 2022 Congress in Seattle, WA.