Antonio Federico, MD, PhD, University of Siena, Siena, Italy, shares an overview of the key topics to be discussed in the plenary sessions at the XXV World Congress of Neurology (WCN 2021). Exciting lectures will take place throughout the congress, focusing on CADASIL (cerebral autosomal dominant arteriopathy with sub-cortical infarcts and leukoencephalopathy), the COVID-19 global pandemic, fluid biomarkers for neurodegeneration, and the use of stem cells in neurological disorder research. This interview took place during the XXV World Congress of Neurology.