Alessio Di Fonzo, MD, PhD, IRCCS Ca’Granda Ospedale Maggiore Policlinico, Milan, Italy, discusses the impact of genetic advancements on the management of patients with Parkinson’s disease. In recent years, our understanding of the importance of genetics in Parkinson’s beyond rare monogenic forms of the disease has grown. Variants associated with more common forms of Parkinson’s have been identified, such as GBA and LRRK2. These advancements have brought about the need for genetic counseling for patients on the meaning of their results for themselves and their families. Additionally, observations of differing disease courses associated with different genetic variants have impacted disease management. This interview took place during the European Academy of Neurology 2021 congress.