Gavin Giovannoni, MBBCh, PhD, FCP, FRCP, FRCPath, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK, discusses the laquinimod clinical trial (NCT02284568). Despite negative results, crucial lessons can be learned from this clinical trial. Prof. Giovannoni believes that using whole brain volume was not the best measurement to access neuroprotection in this trial. The whole brain volume includes components other than neurons and axons, such as astrocytes and microglia. Therefore, in future clinical trials, the same mistakes should not be repeated and another biomarker should be used to assess neuroprotection. This interview took place during the Virtual World Congress on Controversies in Neurology (CONy) 2020.