The identification of REM sleep behavior disorder (RBD) as a prodromal phase of synucleinopathies such as Parkinson’s disease (PD) has allowed the identification of PD patients in early disease phases enabling the study of neuroinflammation and peripheral immune changes observed in the prodromal phase of the disease. Marina Romero-Ramos, PhD, Aarhus University, Aarhus, Denmark, discusses the role of neuroinflammation and immune changes in prodromal PD. Studies have shown that during the prodromal stage of PD, there are inflammatory changes in the brain and immune changes in the blood. The changes in the immune system involve both innate and adaptive immunity. Additionally, evidence suggests that variations in lymphocytes, monocytes, and neutrophils can occur even 20 years before the disease is diagnosed. This, in turn, indicates the significance of the immune system at a very early stage of PD. This interview took place at the 2022 International Congress of Parkinson’s disease and Movement Disorders in Madrid, Spain.
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