Andrew Blumenfeld, MD, The Neurology Center of Southern California, Carlsbad, CA, outlines a real-world retrospective study evaluating the combination of onabotulinumtoxinA and calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) for the control of chronic migraine patients. Patients included in this analysis had failed ≥ 2 oral preventative medications and had been treated with onabotulinumtoxinA for at least 6 months. The average headache frequency was 20 monthly headache days (MHDs) before initiation of onabotulinumtoxinA and 12 MHDs before adding CGRP mAbs. The results showed that combination treatment with onabotulinumtoxinA and CGRP mAbs significantly decreased monthly headache frequency compared to onabotulinumtoxinA monotherapy. This interview took place during the European Academy of Neurology 2021 congress.