Ioannis Sotiropoulos, PhD, Medical School, University of Minho, Braga, Portugal, outlines how chronic stress can precipitate Alzheimer’s disease through depression. Based on recent evidence, chronic stress is a common precipitant suggesting similar neurobiological mechanisms in both disorders where Tau appears as the final executor of neuronal malfunction. This interview was recorded during an online conference call with The Video Journal of Neurology (VJNeurology).