Riikka Lampinen, MSc, University of East Finland, Kuopio, Finland, describes the study of cultured olfactory mucosal (OM) cells derived from nasal biopsies of patients with late-onset Alzheimer’s disease (AD) and age-matched healthy subjects to evaluate disease-specific alterations in these cells. Single-cell RNA sequencing demonstrated that the cultured OM cells from late-onset AD patients displayed pathological features of AD including increased secretion of amyloid beta peptide 42. These results support the potential future use of OM cells as a patient-derived in vitro research model for AD that would allow the study of early-stage disease mechanisms and epigenetic alterations. This interview took place during the AD/PD™ 2021 conference.