Rejko Krüger, MD, University of Luxembourg, Belvaux, Luxembourg, discusses a study investigating a rare mutation in Parkinson’s disease, the DJ-1 gene mutation, which causes loss of DJ-1 protein. Due to the loss of function of DJ-1, homozygous individuals carrying the mutation develop PD at a very early age. The study identified a splicing defect; an exon was skipped, causing a drastic reduction of DJ-1 protein. Using a genetic and pharmacological approach, the investigators were able to restore DJ-1 protein and mitochondrial dysfunction. These results open opportunities for precision medicine strategies in Parkinson’s disease. This interview took place during the AD/PD™ 2021 conference.