Raúl Martínez-Fernandez, MD, PhD, and José Obeso, MD, PhD, University Hospital HM Puerta del Sur, Madrid, Spain, discuss the results from a randomized trial (NCT03454425) of focused ultrasound subthalamotomy for Parkinson’s disease (PD). Abnormal activity of the subthalamic nucleus is responsible for the occurrence of some motor symptoms in PD patients. Therefore, the ultrasound thermal ablation can be used to eliminate this abnormal activity and improve motor signs. The randomized trial evaluated 40 patients that were divided into an active treatment group and a control group (sham procedure). Dr Martínez-Fernandez and Prof. Obeso comment on the safety and efficacy data assessed at four months. This interview took place during the American Academy of Neurology (AAN) 2021 Annual Meeting.