Headache is highly prevalent; therefore, it can occur concurrently with another disorder by chance and without a causal relation. Thus, a secondary headache can be diagnosed only when solid evidence exists that the disorder can cause the headache. Maria-Karina Vélez-Jiménez, MD, Hospital Angeles Lomas, Mexico City, Mexico, discusses the diagnosis of secondary headaches, including the situations when a clinician should suspect of a secondary headache, and reviews the most common secondary headache types. This interview took place during the International Headache Congress 2021.