Nikolaos Grigoriadis, MD, PhD, Aristotle University of Thessaloniki, Thessaloniki, Greece, discusses future strategies to halt disease progression in multiple sclerosis (MS). The optimal approach may involve interfering with microglia and B-cells to control inflammation and, therefore, the neurodegenerative process, using therapeutics such as Bruton’s tyrosine kinase (BTK) inhibitors, which are currently in clinical trials. Early interference with B-cell activity may facilitate macrophage galactose-type lectin (MGL) follicle formation, contributing to demyelination and disease progression. This interview took place during the European Academy of Neurology 2021 congress.