A prodromal stage is an early set of signs and symptoms indicating the onset of a disease. Helen Tremlett, PhD, The University of British Columbia, Vancouver, Canada, discusses the current understanding of the prodromal phase of multiple sclerosis (MS) and describes ongoing studies investigating the MS prodromal presentation. Findings from a study using administrative and clinical data to investigate the years leading up to the onset of MS suggest that individuals who develop MS are more likely to get hospitalized or visit a clinician. More recently, Dr Tremlett’s group has been looking at sex and age differences in healthcare utilization during the MS prodrome. Importantly, although evidence of a prodromal phase in MS has grown, further research is needed to better characterize it. The prodrome could provide valuable insights into the causes of MS and is an opportunity to identify MS earlier and potentially more effectively manage the disease. This interview took place at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) Congress 2022 in Amsterdam, The Netherlands.
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Helen Tremlett has received research support in the last 3 years from the: Canada Research Chair Program, National MS Society, Canadian Institutes of Health Research, Canada Foundation for Innovation, MS Society of Canada, MS Scientific Research Foundation and the EDMUS Foundation (‘Fondation EDMUS contre la sclérose en plaques’).