James F. Howard, Jr., MD, FAAN, University of North Carolina School of Medicine, Chapel Hill, NC, discusses the findings from the REGAIN study (NCT01997229) and its open-label extension trial (NCT02301624) of eculizumab, a terminal complement inhibitor, in patients with refractory anti-acetylcholine receptor antibody-positive generalized myasthenia gravis. Patients experienced rapid improvements with eculizumab across muscle groups and in associated daily activities. These improvements were sustained through the open-label extension. This interview took place during the American Academy of Neurology (AAN) 2021 Annual Meeting.