The outlook for migraine treatment is exciting, with many new therapies under investigation. Jessica Ailani, MD, FAAN, Medstar Georgetown University Hospital, Washington, DC, discusses the current approvals for the treatment of migraine and promising novel medications in the pipeline. At present, several CGRP monoclonal antibodies are approved for migraine prevention, and two gepants are available for acute migraine treatment. Zavegepant is a third-generation selective small molecule CGRP receptor antagonist that has recently completed a Phase II trial (NCT03872453) using intranasal administration for acute migraine treatment. A number of novel gepants are also under investigation in the preventative setting, including rimegepant and atogepant. This interview took place during the American Academy of Neurology (AAN) 2021 Annual Meeting.