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AD/PD 2021 | The influence of the gut microbiome on amyloid-beta

Sangram Sisodia, PhD, University of Chicago, Chicago, IL, describes research evaluating the influence of the gut microbiome on the modulation of neuroinflammation and amyloid-beta deposition in Alzheimer’s disease. It has been demonstrated, in mouse models, that antibody treatments that alters the composition of the microbiota result in reduced amyloid-beta plaque burden in males although interestingly, not females. Future research which will involve fecal transplantation experiments in germ-free mice to better understand these sex-specific differences, the role of microglia and other underlying mechanisms, molecules and bacterial strains involved in this pathophysiological process. This interview took place during the AD/PD™ 2021 conference.