Serge Przedborski, MD, PhD, Columbia University Irving Medical Center, New York, NY, discusses the role of lipids in synucleinopathies. Discoveries from genetic studies have pointed to risk factors for Parkinson’s disease (PD) in a number of enzymes involved in lipid metabolism, leading to the hypothesis that lipids play a central role in synucleinopathies. Research investigating the role of lipids in PD can be looked at from two perspectives: examining alterations in lipid metabolism to inform us about the disease biology, or if alterations are detected, they can be used as biomarkers, which is an area of unmet need in the field. Lipidomics is an emerging field that can provide novel insights into PD pathology and diagnosis. This interview took place at the 2022 International Congress of Parkinson’s Disease and Movement Disorders in Madrid, Spain.
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