Ioannis Sotiropoulos, PhD, Medical School, University of Minho, Braga, Portugal, outlines the role of Tau in brain physiology and pathology. Dr Sotiropoulos reveals that Tau is not only involved in Alzheimer’s disease, as there is recent evidence that chronic stress and depression could also include neuronal malfunction through tau. This interview was recorded during an online conference call with The Video Journal of Neurology (VJNeurology).