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AAN 2022 | Diagnostic work up of autoimmune neurological conditions

Divyanshu Dubey, MBBS, Mayo Clinic, Rochester, MN, shares his approach to diagnosing and treating autoimmune neurological conditions. Initially, it is important to assess the patient and distinguish between nerve, muscle, and muscular junction problems. Electromyography (EMG) and nerve conduction studies (NCS) provide helpful information during the diagnostic workup. Based on clinical and diagnostic assessment, neuropathies can be subcategorized into different phenotypes. The initial clinical categorization helps understand which antibody evaluations are helpful. Finally, the antibody test results support the treatment decision. This interview took place at the American Academy of Neurology 2022 Congress in Seattle, WA.


Dr Dubey has consulted for UCB, Immunovant and Astellas Pharmaceuticals. All compensation for consulting activities is paid directly to Mayo Clinic. Dr Dubey has patents pending for Kelch-like protein 11 (KLHL11) IgG and Leucine Zipper 4 (LUZP4) IgG as markers of neurological autoimmunity.