Dimos-Dimitrios Mitsikostas, MD, PhD, National & Kapodistrian University of Athens, Athens, Greece, introduces the upcoming Pan-European Real Life (PEARL) study, assessing the effectiveness of fremanezumab for migraine prevention in patients with chronic or episodic migraine. The 24-month prospective, observational trial will assess the reduction in monthly migraine days, disability scores, adherence, and acute headache medication use. Prof. Mitsikostas highlights the importance of real-world data to provide evidence of the effectiveness of calcitonin gene-related peptide (CGRP)-targeted monoclonal antibodies. This interview took place during the European Academy of Neurology 2021 congress.