ACTRIMS 2021 | Clinical presentation and management of paraneoplastic neurological syndromes

Divyanshu Dubey, MBBS, Mayo Clinic, Rochester, MN, shares the details of a review of paraneoplastic neurological syndromes (PNS), recently published in Therapeutic Advances in Neurological Disorders. PNS are a group of neurological disorders resulting from autoimmune responses mounted against the nervous system during an antitumor immune response. Onconeural antigens expressed by the tumor and released after cell death, are also expressed in the nervous system, leading to autoimmune attack. The review discusses the various classic and non-classic syndromes that occur, neural-specific antibodies with oncological association, and immunotherapy-based management of PNS. This interview took place during the ACTRIMS Forum 2021.