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ESOC 2021 | Stronger associations between major risk factors and the risk of stroke in women compared to men

Sanne Peters, PhD, George Institute for Global Health, Imperial College London, London, UK, outlines an investigation into sex differences in the association between modifiable risk factors and the occurrence of stroke, including individual stroke subtypes. By involving over 470,000 UK Biobank participants without any history of cardiovascular disease, multiple risk factors were found to be more strongly associated with the risk of any stroke and stroke subtypes in women compared to men. For example, stronger associations were found between diabetes and acute ischemic stroke risk, and atrial fibrillation and hemorrhagic stroke risk. Hypertension, smoking, and a low socioeconomic status were associated with a greater hazard ratio of any stroke in women than in men. Despite the stronger associations in women between specific risk factors and the risk of any stroke or stroke subtypes, the overall incidence of stroke was greater in men compared to women. This interview took place at the European Stroke Organisation Conference (ESOC), 2021.