Dimos-Dimitrios Mitsikostas, MD, PhD, National & Kapodistrian University of Athens, Athens, Greece, comments on the recent developments in the field of headache research. Whilst the treatment landscape for migraines have vastly improved over recent years, novel discoveries are still being made. Additional pain pathways represent promising targets for migraines and data from upcoming trials will hopefully expand the current armamentarium. This interview was conducted during the 2022 World Congress on Controversies in Neurology (CONy) meeting.