Claudia Trenkwalder, MD, University Medical Center of Göttingen, Göttingen, Germany, discusses transcranial sonography (TCS) of the substantia nigra, an imaging technique that has been used in the investigation of Parkinson’s disease. Prof. Trenkwalder first mentions some data which found that the substantia nigra in patients with Parkinson’s disease is often enlarged with an area of hyperechogenicity. Prof. Trenkwalder then discusses how this ultrasound technique provides an additional biomarker for disease, as well as other benefits of using TCS in Parkinson’s disease. This interview took place during the World Sleep Congress 2022 in Rome, Italy.