Matthew Walker, MA, MB BChir, PhD, FRCP, University College London Hospital, London, UK, discusses whether enzyme-inducing antiseizure medications should be avoided due to their side effects. As many drugs will have multiple mechanisms of action, prescribing a certain medication solely based on their mechanism will be difficult. When a patient additionally progresses on a certain treatment, assessing whether it was due to the toxicity or lack of efficacy is important to determine what the next course of action is and Prof. Walker also describes the potential synergistic benefits of combining multiple therapies with similar mechanisms of action. This interview was conducted during the 2022 World Congress on Controversies in Neurology (CONy) meeting.