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BNA 2023 | Investigating the glymphatic system in neurodegenerative diseases

Ian Harrison, PhD, University College London, London, UK, comments on the rationale for investigating the role of the glymphatic system in neurodegenerative diseases, such as Parkinson’s disease (PD) and Alzheimer’s disease (AD). The glymphatic system is responsible for clearance of interstitial solutes throughout the central nervous system. Since toxic protein accumulation is a hallmark of both these diseases, several research groups are looking at the potential role of glymphatic impairment in disease exacerbation. Of particular interest to Dr Harrison is the role of aquaporin-4 in facilitating clearance and how this could be manipulated therapeutically. This interview took place at The BNA 2023 International Festival of Neuroscience in Brighton, UK.

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