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WSC 2022 | Key research questions in cerebral amyloid angiopathy

There has been a rapid increase in research in the cerebral amyloid angiopathy (CAA) field in recent years. Hsin-Hsi Tsai, MD, National Taiwan University Hospital, Taipei, Taiwan, discusses the most important lines of research in CAA. Firstly, the development of novel neuroimaging biomarkers to improve diagnostic accuracy and further our understanding of disease pathophysiology is an important research focus. The presence of hemorrhagic markers on MRI allows a diagnosis of probable CAA, however, there are atypical scenarios where diagnosis is less definite. Ultra-high field functional MRI is being used to study novel imaging features. There is also a need to gain insight into different CAA phenotypes. Accumulating evidence shows that CAA can have non-hemorrhagic manifestations, such as cognitive impairment and neuroinflammation. Lastly, developing therapeutic options is the most important need. As our understanding of the clinical and radiological spectrum of CAA evolves, identifying target mechanisms for intervention is a major unmet need. This interview took place at the World Stroke Congress 2022 in Singapore.

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