George Perry, PhD, The University of Texas at San Antonio, San Antonio, TX, discusses the role of oxidative stress in the pathogenesis of Alzheimer’s disease. Studies have shown that oxidative stress precedes the cardinal neuropathologic manifestations of Alzheimer’s disease. Additionally, oxidative modifications are seen in brain tissue in the early phases of the disease. Evidence indicates that pathological hallmarks of Alzheimer’s disease, namely aggregation of amyloid-β, are adaptive responses to underlying oxidative stress rather than harmful. This interview was conducted during the virtual 2021 World Congress on Controversies in Neurology (CONy).