Jessica Ailani, MD, FAAN, Medstar Georgetown University Hospital, Washington, DC, shares an overview of the topics discussed in the ‘Comprehensive migraine update’ session at the AAN 2021 virtual annual meeting. The case-based session reviewed updates in migraine treatment that have occurred over the last 3 years. Key topics included how to diagnose patients effectively and quickly, optimal treatment approaches, where newer treatment options should fit in the migraine treatment paradigm, and the importance of shared decision making. This interview took place during the American Academy of Neurology (AAN) 2021 Annual Meeting.