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EHDN 2022 | Targeting dysregulated axonal transport in Huntington’s disease

Huntingtin (HTT) plays an important role in facilitating axonal transport, notably the transport of BDNF vesicles within the corticostriatal circuitry. Microtubule motor complexes associate with these vesicles via HTT, enabling both anterograde and retrograde transport of BDNF. When HTT is mutated in Huntington’s disease, transport efficiency is much reduced, leading to impairments in synaptic maintenance and neuronal communication, and thus, sensitization of striatal and cortical neurons to neurodegeneration. Frederic Saudou, PhD, Université Grenoble Alpes, Grenoble, France, discusses strategies under investigation to target this system and restore axonal transport efficiency. Modifying mutant HTT conformation and increasing the affinity of the molecular motor are some examples of potential therapeutic approaches. This interview took place during the European Huntington’s Disease Network 2022 Plenary Meeting.

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