Ermelinda De Meo, MD, University Vita-Salute San Raffaele, Milan, Italy, comments on the progress and future research needed in the field of multiple sclerosis (MS). Dr De Meo mentions that research on progressive MS needs to expand to include more clinical evidence on the efficacy of new drugs. Moreover, treatment efficacy on cognitive features of the disease needs to be targeted. This interview took place during the American Academy of Neurology (AAN) 2021 Annual Meeting