Amit Bar-Or, MD, FRCPC, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, discusses the current treatment options in multiple sclerosis (MS), as well as the greatest unmet needs facing the field and areas of significant research focus for the near future. The MS treatment landscape has markedly evolved over the last few years, with many more effective therapies available. Early administration of disease modifying therapies has allowed successful prevention of relapses, but targeting progressive disease biology and repairing established damage has proved more difficult. Dr Bar-Or shares some of the approaches currently under investigation to address these unmet needs. This interview took place during the ACTRIMS Forum 2021.