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ACTRIMS 2022 | Outcome disparities in African American and Hispanic patients with MS

Mitzi Joi Williams, MD, Joi Life Wellness Group, Smyrna, GA, talks on outcome disparities in non-white patients with multiple sclerosis (MS). Dr Williams explains that a growing body of evidence suggests that there might be differences in outcomes in specific populations, particularly African American and Hispanic American patients. Those patients seem to experience a higher level of disability and show different MRI characteristics. It is important to understand the reasons for those disparities and how social determinants of health interact with potential biological differences. Therefore, it is essential to increase the enrollment of minority populations in clinical trials. This interview took place at the ACTRIMS Forum 2022 in West Palm Beach, Florida.

Transcript (edited for clarity)

There’s a growing body of research that suggests that there may be differences in outcomes that we see in certain populations. For instance, African Americans and Hispanic/Latino patients may have more disability, may have more walking problems, may have different characteristics on MRI. I think that all of this research focused on outcomes really lends itself to us kind of taking a step back and trying to understand why we see the outcomes that we see...

There’s a growing body of research that suggests that there may be differences in outcomes that we see in certain populations. For instance, African Americans and Hispanic/Latino patients may have more disability, may have more walking problems, may have different characteristics on MRI. I think that all of this research focused on outcomes really lends itself to us kind of taking a step back and trying to understand why we see the outcomes that we see. One of the difficulties with understanding the role of social determinants of health, like access to the physician, discrimination and bias within the medical system, how they interact with potential biological differences, is that we have very low enrollment of people of color in our clinical trials for multiple sclerosis.

That’s something that myself and many of my colleagues are actively working on trying to change, thinking about the way we design trials, those who are involved in trials, encouraging people of color to become involved in neuroscience. I think all of those things will help us to better understand why we see the outcomes we see.

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Disclosures

Mitzi Joi Williams reports the following disclosures:
Research Support: EMD Serono; Genentech; and Novartis
Advisory Committee/ Consultant: AbbVie; Biogen Idec; Bristol Myers Squibb; EMD Serono; Genentech; Novartis; Sanofi Genzyme; Janssen; Alexion; and TG Therapeutics
Speaker Bureau: AbbVie; Biogen Idec; Bristol Myers Squibb; EMD Serono; Genentech; Novartis; Sanofi Genzyme, Janssen