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Pregnancy management in MS and NMOSD

Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are chronic conditions of the central nervous system, predominantly affecting women of childbearing age. Hence pregnancy planning is significant in patients with MS and NMOSD. Although MS and NMOSD share some common symptoms, both have a different impact on pregnancy. MS is a chronic inflammatory demyelinating condition caused by the activation of pro-inflammatory mechanisms. However, in pregnancy, these mechanisms are suppressed, leading to decreased disease activity. Unlike MS, NMOSD is an antibody-mediated disease associated with increased disease activity during pregnancy, postpartum disabilities, and complications like fetal loss and preeclampsia in pregnancy.

In this podcast, Melinda Magyari, MD, PhD, The Danish Multiple Sclerosis Center, University of Copenhagen, Copenhagen, Denmark; Eva Kubala Havrdov√°, MD, PhD, General University Hospital, Charles University, Prague, Czechia; and Celia Oreja-Guevara, MD, PhD, University Hospital San Carlos, Madrid, Spain, will review the current treatment guidelines for MS and NMOSD treatment during pregnancy and discuss results from recent studies looking at pregnancy and infant outcomes.

Date: 25th November 2022